Leslie Spier, 1893-1961

Evolvability LESLIE

Living organisms function in accordance with complex mechanisms that operate in different ways depending on conditions. Darwin’s theory of evolution suggests that such mechanisms evolved through variation guided by natural selection. However, there has existed no theory that would explain quantitatively which mechanisms can so evolve in realistic population sizes within realistic time periods, ...

Leslie Matthews

Op-brai150105 1875..1893

Remyelination failure plays an important role in the pathophysiology of multiple sclerosis, but the underlying cellular and molecular mechanisms remain poorly understood. We now report actively demyelinating lesions in patients with multiple sclerosis are associated with increased glial expression of fibroblast growth factor 9 (FGF9), which we demonstrate inhibits myelination and remyelination ...

Dev105650 1884..1893

During morphogenesis, organs grow to stereotyped sizes, but growth control mechanisms are poorly understood. Here, we measured the signaling dynamics of the morphogen Dpp, one of several Drosophila factors controlling morphogenetic growth, in the developing eye. In this tissue, the Dpp expression domain advances from the posterior to the anterior tissue edge. In front of this moving morphogen s...

Dev117903 1893..1908

Malformation of the urogenital tract represents a considerable paediatric burden, with many defects affecting the lower urinary tract (LUT), genital tubercle and associated structures. Understanding the molecular basis of such defects frequently draws on murine models. However, human anatomical terms do not always superimpose on the mouse, and the lack of accurate and standardised nomenclature ...